The campaign to persuade Transport for London (TfL) not to amalgamate the 312 and 412 services has been taken up by London Assembly member Murad Qureshi.
Mr Qureshi asked the mayor to review the situation, which he claimed would lead to more overcrowding and a reduced service for people living near Croydon Bus Garage, in Brighton Road.
The TfL proposals involve withdrawing the 412 route, which serves Purley, Sanderstead and Selsdon.
The 312 route, which runs from the bus garage to Norwood Junction via East Croydon station, would no longer serve the garage.
Instead, it would divert on the journey from Norwood Junction at the Swan and Sugar Loaf pub in South Croydon and follow the 412 route to Sanderstead, Selsdon and then on to Purley.
Opponents to the changes have organised a petition to TfL, urging a rethink.
The petition claims the 312 is the only bus during the peak hours on which people living near the bus garage can guarantee to find a place.
In reply to Mr Qureshi’s request, the mayor said TfL was considering feedback from residents and would write to them "once a final decision is made."
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